Asymmetric synthesis of enaminophosphines via palladacycle-catalyzed addition of Ph2PH to α,β-unsaturated imines

• Main Authors: Pullarkat, Sumod A., Huang, Yinhua, Chew, Renta Jonathan, Li, Yongxin, Leung, Pak-Hing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/96145; http://hdl.handle.net/10220/17050
• Institution: Nanyang Technological University

A highly reactive, chemo- and enantioselective addition of diphenylphosphine to α,β-unsaturated imines catalyzed by a palladacycle has been developed, thus providing the access to a series of chiral tertiary enaminophosphines in high yields. A putative catalytic cycle has also been proposed.