Comprehensive analysis and identification of the human STIM1 domains for structural and functional studies

• Main Authors: Eshaghi, Said, How, Jonathan, Zhang, Ai, Phillips, Margaret, Reynaud, Aline, Lu, Si Yan, Pan, Lucy Xin, Ho, Hai Ting, Yau, Yin Hoe, Guskov, Albert, Pervushin, Konstantin, Shochat, Susana Geifman
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96538; http://hdl.handle.net/10220/9897
• Institution: Nanyang Technological University

STIM1 is a Ca2+ sensor within the ER membrane known to activate the plasma membrane store-operated Ca2+ channel upon depletion of its target ion in the ER lumen. This activation is a crucial step to initiate the Ca2+ signaling cascades within various cell types. Human STIM1 is a 77.4 kDa protein c...