Dissociation of hydrophobic and charged nano particles in aqueous guanidinium chloride and urea solutions : a molecular dynamics study

It has been a long history that urea and guanidinium chloride (GdmCl) are used as agents for denaturing proteins. The underlying mechanism has been extensively studied in the past several decades. However, the question regarding why GdmCl is much stronger than urea has seldom been touched. Here, thr...

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Bibliographic Details
Main Authors: Li, Weifeng, Mu, Yuguang
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97361
http://hdl.handle.net/10220/10744
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Institution: Nanyang Technological University
Language: English