Salting effects on protein components in aqueous NaCl and urea solutions : toward understanding of urea-induced protein denaturation

• المؤلفون الرئيسيون: Mu, Yuguang, Li, Weifeng, Zhou, Ruhong
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Chemistry::Analytical chemistry::Proteins
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99763; http://hdl.handle.net/10220/17180

The mechanism of urea-induced protein denaturation is explored through studying the salting effect of urea on 14 amino acid side chain analogues, and N-methylacetamide (NMA) which mimics the protein backbone. The solvation free energies of the 15 molecules were calculated in pure water, aqueous urea...