Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies

Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of...

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Main Authors: Prasad, Paras N., Liu, Liwei, Yong, Ken-Tye, Roy, Indrajit, Law, Wing-Cheung, Ye, Ling, Liu, Jianwei, Liu, Jing, Kumar, Rajiv, Zhang, Xihe
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/97423
http://hdl.handle.net/10220/11854
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-974232022-02-16T16:28:56Z Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies Prasad, Paras N. Liu, Liwei Yong, Ken-Tye Roy, Indrajit Law, Wing-Cheung Ye, Ling Liu, Jianwei Liu, Jing Kumar, Rajiv Zhang, Xihe School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice. Published Version 2013-07-18T03:59:57Z 2019-12-06T19:42:37Z 2013-07-18T03:59:57Z 2019-12-06T19:42:37Z 2012 2012 Journal Article Liu, L., Yong, K.-T., Roy, I., Law, W.-C., Ye, L., Liu, J., et al. (2012). Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies. Theranostics, 2(7), 705-713. 1838-7640 https://hdl.handle.net/10356/97423 http://hdl.handle.net/10220/11854 10.7150/thno.3456 22896772 en Theranostics © 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Electrical and electronic engineering
spellingShingle DRNTU::Engineering::Electrical and electronic engineering
Prasad, Paras N.
Liu, Liwei
Yong, Ken-Tye
Roy, Indrajit
Law, Wing-Cheung
Ye, Ling
Liu, Jianwei
Liu, Jing
Kumar, Rajiv
Zhang, Xihe
Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
description Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Prasad, Paras N.
Liu, Liwei
Yong, Ken-Tye
Roy, Indrajit
Law, Wing-Cheung
Ye, Ling
Liu, Jianwei
Liu, Jing
Kumar, Rajiv
Zhang, Xihe
format Article
author Prasad, Paras N.
Liu, Liwei
Yong, Ken-Tye
Roy, Indrajit
Law, Wing-Cheung
Ye, Ling
Liu, Jianwei
Liu, Jing
Kumar, Rajiv
Zhang, Xihe
author_sort Prasad, Paras N.
title Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
title_short Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
title_full Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
title_fullStr Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
title_full_unstemmed Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
title_sort bioconjugated pluronic triblock-copolymer micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies
publishDate 2013
url https://hdl.handle.net/10356/97423
http://hdl.handle.net/10220/11854
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