Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands
We report herein the first examples of asymmetric Mizoroki–Heck reactions using benzyl electrophiles. A new phosphoramidite was identified to be an effective chiral ligand in the palladium–catalyzed reaction. The reaction is compatible with polar functional groups and can be readily scaled up. Sever...
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sg-ntu-dr.10356-975952020-03-07T12:31:21Z Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands Yang, Zhigang Zhou, Jianrong Steve School of Physical and Mathematical Sciences We report herein the first examples of asymmetric Mizoroki–Heck reactions using benzyl electrophiles. A new phosphoramidite was identified to be an effective chiral ligand in the palladium–catalyzed reaction. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components. Thirty-one examples are included. 2013-07-11T07:56:18Z 2019-12-06T19:44:26Z 2013-07-11T07:56:18Z 2019-12-06T19:44:26Z 2012 2012 Journal Article Yang, Z., & Zhou, J. S. (2012). Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands. Journal of the American chemical society, 134(29), 11833-11835. https://hdl.handle.net/10356/97595 http://hdl.handle.net/10220/11228 10.1021/ja304099j en Journal of the American chemical society © 2012 American Chemical Society. |
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We report herein the first examples of asymmetric Mizoroki–Heck reactions using benzyl electrophiles. A new phosphoramidite was identified to be an effective chiral ligand in the palladium–catalyzed reaction. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components. Thirty-one examples are included. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Yang, Zhigang Zhou, Jianrong Steve |
| format |
Article |
| author |
Yang, Zhigang Zhou, Jianrong Steve |
| spellingShingle |
Yang, Zhigang Zhou, Jianrong Steve Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| author_sort |
Yang, Zhigang |
| title |
Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| title_short |
Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| title_full |
Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| title_fullStr |
Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| title_full_unstemmed |
Palladium-catalyzed, asymmetric Mizoroki–Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| title_sort |
palladium-catalyzed, asymmetric mizoroki–heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/97595 http://hdl.handle.net/10220/11228 |
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1681043555047440384 |