Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

• Main Authors: Tieu, William, Zvarec, Ondrej, Bell, Jan M., Turnidge, John D., Wallace, John C., Soares da Costa, Tatiana P., Yap, Min Y., Booker, Grant W., Wilce, Matthew C. J., Abell, Andrew D., Polyak, Steven W.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/97854; http://hdl.handle.net/10220/12344
• Institution: Nanyang Technological University

There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target for new antibiotics. We report the synthesis a...