Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase
There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target for new antibiotics. We report the synthesis a...
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Main Authors: | Tieu, William, Zvarec, Ondrej, Bell, Jan M., Turnidge, John D., Wallace, John C., Soares da Costa, Tatiana P., Yap, Min Y., Booker, Grant W., Wilce, Matthew C. J., Abell, Andrew D., Polyak, Steven W. |
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Other Authors: | School of Materials Science & Engineering |
Format: | Article |
Language: | English |
Published: |
2013
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Online Access: | https://hdl.handle.net/10356/97854 http://hdl.handle.net/10220/12344 |
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Institution: | Nanyang Technological University |
Language: | English |
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