Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents

• Main Authors: Ngampong Kongkathip, Narathip Pradidphol, Komkrit Hasitapan, Ronald Grigg, Wei Chun Kao, Carola Hunte, Nicholas Fisher, Ashley J. Warman, Giancarlo A. Biagini, Palangpon Kongsaeree, Pitak Chuawong, Boonsong Kongkathip
• Other Authors: Kasetsart University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/28775
• Institution: Mahidol University

Twenty-six novel naphthoquinone aliphatic esters were synthesized by esterification of 1,4-naphthoquinone alcohols with various aliphatic acids. The 1,4-naphthoquinone alcohols were prepared from 1-hydroxy-2-naphthoic acid in nine steps with excellent yields. Twenty-four of the novel synthetic napht...