Synthesis of novel rhinacanthins and related anticancer naphthoquinone esters

• Main Authors: Ngampong Kongkathip, Suwaporn Luangkamin, Boonsong Kongkathip, Chak Sangma, Ronald Grigg, Palangpon Kongsaeree, Samran Prabpai, Narathip Pradidphol, Suratsawadee Piyaviriyagul, Pongpun Siripong
• Other Authors: Kasetsart University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21165
• Institution: Mahidol University

Rhinacanthin-M, -N and -Q, natural products isolated from the medicinal plant Rhinacanthus nasutus, and 39 novel naphthoquinone esters have been synthesized in excellent yield by esterification of naphthoquinone-3-(propan- 3′-ols) with benzoic or naphthoic acids. Almost all the naphthoquinone esters...