Potent antitumor activity of synthetic 1,2-naphthoquinones and 1,4-naphthoquinones

Potent antitumor activity of synthetic 1,2-naphthoquinones and 1,4-naphthoquinones

Rhinacanthone (1) and two 1,2-pyranonaphthoquinones (2,3) were synthesized and found to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG2) with IC50values of 0.92-9.63 μM, whereas the corresponding hydroxylated derivative 4 had reduced cytotoxicity (IC50values of 7.61...

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Bibliographic Details
Main Authors: Ngampong Kongkathip, Boonsong Kongkathip, Pongpun Siripong, Chak Sangma, Suwaporn Luangkamin, Momad Niyomdecha, Suppachai Pattanapa, Suratsawadee Piyaviriyagul, Palangpon Kongsaeree
Other Authors: Kasetsart University
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/20708
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Institution: Mahidol University

Internet

https://repository.li.mahidol.ac.th/handle/123456789/20708

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