Molecular basis of converting proteases to ligases

• المؤلف الرئيسي: Chang, Hong Yi
• مؤلفون آخرون: James P Tam
• التنسيق: Final Year Project
• اللغة: English
• منشور في: Nanyang Technological University 2020
• الموضوعات: Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/140892

Peptide asparaginyl ligases (PALs) are an unusual subgroup of asparaginyl endopeptidases (AEPs). They share the same protein structure but catalyse different reactions. AEPs hydrolyse the Asx (Asn/Asp)-Xaa bond while PALs ligate them. PALs are the processing enzymes that mediate the backbone cycliza...