Ligase-controlled cyclo-oligomerization of peptides

A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino aci...

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Bibliographic Details
Main Authors: Hemu, Xinya, Zhang, Xiaohong, Tam, James P.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Online Access:https://hdl.handle.net/10356/143886
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Institution: Nanyang Technological University
Language: English