pH-controlled protein orthogonal ligation using asparaginyl peptide ligases

pH-controlled protein orthogonal ligation using asparaginyl peptide ligases

Peptide asparaginyl ligases (PALs) catalyze transpeptidation at the Asn residue of a short Asn-Xaa1-Xaa2 tripeptide motif. Due to their high catalytic activity toward the P1-Asn substrates at around neutral pH, PALs have been used extensively for peptide ligation at asparaginyl junctions. PALs also...

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Bibliographic Details
Main Authors: Zhang, Dingpeng, Wang, Zhen, Hu, Side, Balamkundu, Seetharamsing, To, Janet, Zhang, Xiaohong, Lescar, Julien, Tam, James P., Liu, Chuan-Fa
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Peptide Asparaginyl Ligase
Biocatalysis
Online Access:https://hdl.handle.net/10356/159343
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/159343

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