Structural determinants for peptide-bond formation by asparaginyl ligases

Structural determinants for peptide-bond formation by asparaginyl ligases

Asparaginyl endopeptidases (AEPs) are cysteine proteases which break Asx (Asn/Asp)-Xaa bonds in acidic conditions. Despite sharing a conserved overall structure with AEPs, certain plant enzymes such as butelase 1 act as a peptide asparaginyl ligase (PAL) and catalyze Asx-Xaa bond formation in near-n...

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Bibliographic Details
Main Authors: Hemu, Xinya, El Sahili, Abbas, Hu, Side, Wong, Kaho, Chen, Yu, Wong, Yee Hwa, Zhang, Xiaohong, Serra, Aida, Goh, Boon Chong, Darwis, Dina Amallia, Chen, Ming Wei, Sze, Siu Kwan, Liu, Chuan-Fa, Lescar, Julien, Tam, James P.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science
Asparaginyl Ligase
Cyclopeptide
Online Access:https://hdl.handle.net/10356/148284
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/148284

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