Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors of HCV NS5B polymerase

• Main Authors: Harikishore, Amaravadhi, Li, Enlin, Lee, Jia Jun, Cho, Nam-Joon, Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/97886; http://hdl.handle.net/10220/38515
• Institution: Nanyang Technological University

Hepatitis C virus (HCV) infection or HCV-related liver diseases are now shown to cause more than 350,000 deaths every year. Adaptability of HCV genome to vary its composition and the existence of multiple strains makes it more difficult to combat the emergence of drug-resistant HCV infections. Among...