A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

• Main Authors: Claessens, Antoine, Adams, Yvonne, Ghumra, Ashfaq, Lindergard, Gabriella, Andisi, Cheryl, Mok, Sachel, Turner, Louise, Arman, Mònica, Raza, Ahmed, Bozdech, Zbynek, Rowe, J. Alexandra, Buchan, Caitlin C., Bull, Peter C., Gupta, Archna P., Wang, Christian W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98020; http://hdl.handle.net/10220/12358
• Institution: Nanyang Technological University

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human rec...