Iron-oxide nanoparticles mediated cyclization of 3-(4-chlorophenyl)-1-hydrazinylisoquinoline to 1-(4,5-dihydropyrazol-1-yl)isoquinolines

• Main Authors: Jin, Jong Sung, Jeong, Euh Duck, Kim, Hyun Gyu, Maiyalagan, Thandavarayan, Nawaz Khan, F., Manivel, P., Prabakaran, K.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/98048; http://hdl.handle.net/10220/12216
• Institution: Nanyang Technological University

Iron-oxide nanoparticles were obtained using chitosan templates and their crystalline character and particle size have been confirmed through powder x-ray diffraction and transmission electron microscopy measurements. The particle sizes were found to be 10–25 nm. The diversified chalcones 2 were reacted with 1-hydrazinylisoquinoline 1 in the presence of iron-oxide nanoparticles to the corresponding pyrazolines 3a–j in high yield and purity. The pyrazolines were characterized by spectroscopic techniques.