Synthesis and characterization of 5-bromo-6-(4-chlorophenyl)-2-propylimidazol[2,1-b][1,3,4]thiadiazole: A potential anti-cancer drug

• Main Authors: Ocampo, Charlene Q., Mercado, Jouella Camille Q., Alea, Glenn V., Oyong, Glenn G., Lagua, Faith Marie G.
• Format: text
• Published: Animo Repository 2015
• Subjects: Imidazoles—Synthesis; Antineoplastic agents; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11446
• Institution: De La Salle University

An imidazo[2,1-b][1,3,4]thiadiazole derivative, 5-bromo-6-(4-chlorophenyl)-2- propylimidazo[2,1-b][1,3,4]thiadiazole (5) was synthesized and characterized. The synthesis involved the preparation of an acylated thiosemicarbazide derivative (3) via nucleophilic acyl substitution, followed by dehydrocy...