New imidazo[2,1-b][1,3,4]thiadiazole derivatives of thiazolidine-2,4-dione and rhodanine-3-acetic acid: Synthesis, characterization, evaluation of TGF-βRI inhibitory activity, cytotoxicity studies and mesoporous silica nanoparticle (MSN) delivery studies
New imidazothiadiazole derivatives of thiazolidine-2,4-dione (8a-b) and rhodanine-3-acetic acid (7a-b) were synthesized and characterized. The synthesis involved the preparation of 5-(6-methylpyridin-2-yl)-1,3,4-thiadiazol-2-amine (4) followed by the condensation with different alpha-haloketones to...
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Animo Repository
2019
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_doctoral/1448 https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=2495&context=etd_doctoral |
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| Institution: | De La Salle University |