A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing

A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing

A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by opt...

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Main Authors: Wang, Fei, Yu, Hao, Yeo, Kiat Seng, Guo, Jing, Huang, Xiwei, Yan, Mei
Other Authors: School of Electrical and Electronic Engineering
Format: Conference or Workshop Item
Language:English
Published: 2015
Subjects:
DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits
Online Access:https://hdl.handle.net/10356/98112
http://hdl.handle.net/10220/38537
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-981122020-03-07T13:24:48Z A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei School of Electrical and Electronic Engineering 2014 Symposium on VLSI Circuits Digest of Technical Papers DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps. . Accepted version 2015-08-27T09:00:57Z 2019-12-06T19:50:42Z 2015-08-27T09:00:57Z 2019-12-06T19:50:42Z 2014 2014 Conference Paper Huang, X., Wang, F., Guo, J., Yan, M., Yu, H., & Yeo, K. S. (2014). A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing. 2014 Symposium on VLSI Circuits Digest of Technical Papers. https://hdl.handle.net/10356/98112 http://hdl.handle.net/10220/38537 10.1109/VLSIC.2014.6858409 en © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [http://dx.doi.org/10.1109/VLSIC.2014.6858409]. 4 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits
spellingShingle DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits
Wang, Fei
Yu, Hao
Yeo, Kiat Seng
Guo, Jing
Huang, Xiwei
Yan, Mei
A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
description A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps. .
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Wang, Fei
Yu, Hao
Yeo, Kiat Seng
Guo, Jing
Huang, Xiwei
Yan, Mei
format Conference or Workshop Item
author Wang, Fei
Yu, Hao
Yeo, Kiat Seng
Guo, Jing
Huang, Xiwei
Yan, Mei
author_sort Wang, Fei
title A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
title_short A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
title_full A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
title_fullStr A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
title_full_unstemmed A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
title_sort 64×64 1200fps cmos ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput dna sequencing
publishDate 2015
url https://hdl.handle.net/10356/98112
http://hdl.handle.net/10220/38537
_version_ 1681038138750795776

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