Weak glycolipid binding of a microdomain-tracer peptide correlates with aggregation and slow diffusion on cell membranes

• Main Authors: Wohland, Thorsten, Kraut, Rachel, Geifman-Shochat, Susana, Lauterbach, Tim, Manna, Manoj, Ruhnow, Maria, Wisantoso, Yudi, Wang, Yaofeng, Matysik, Artur, Oglęcka, Kamila, Mu, Yuguang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98127; http://hdl.handle.net/10220/10899
• Institution: Nanyang Technological University

Organized assembly or aggregation of sphingolipid-binding ligands, such as certain toxins and pathogens, has been suggested to increase binding affinity of the ligand to the cell membrane and cause membrane reorganization or distortion. Here we show that the diffusion behavior of the fluorescently t...