Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides

• Main Authors: Zhou, Y., Kierzek, E., Loo, Z. P., Antonio, M., Yau, Yin Hoe, Chuah, Y. W., Geifman-Shochat, Susana, Kierzek, R., Chen, Gang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/98149; http://hdl.handle.net/10220/13310
• Institution: Nanyang Technological University

Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs) may be developed to...