Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine–purine inversion site of an RNA duplex

Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine–purine inversion site of an RNA duplex

RNA duplex regions are often involved in tertiary interactions and protein binding and thus there is great potential in developing ligands that sequence-specifically bind to RNA duplexes. We have developed a convenient synthesis method for a modified peptide nucleic acid (PNA) monomer with a guanidi...

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Bibliographic Details
Main Authors: Toh, Desiree-Faye Kaixin, Devi, Gitali, Patil, Kiran M., Qu, Qiuyu, Maraswami, Manikantha, Xiao, Yunyun, Loh, Teck Peng, Zhao, Yanli, Chen, Gang
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2017
Subjects:
Cytosine
DNA
Online Access:https://hdl.handle.net/10356/84061
http://hdl.handle.net/10220/42924
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/84061
http://hdl.handle.net/10220/42924

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