Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites

• Main Authors: Hammam, Elie, Ananda, Guruprasad, Sinha, Ameya, Scheidig-Benatar, Christine, Bohec, Mylene, Preiser, Peter Rainer, Dedon, Peter C., Scherf, Artur, Vembar, Shruthi S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Cytosine; DNA
• Online Access: https://hdl.handle.net/10356/145154
• Institution: Nanyang Technological University

DNA cytosine modifications are key epigenetic regulators of cellular processes in mammalian cells, with their misregulation leading to varied disease states. In the human malaria parasite Plasmodium falciparum, a unicellular eukaryotic pathogen, little is known about the predominant cytosine modific...