Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine–purine inversion site of an RNA duplex

• Main Authors: Toh, Desiree-Faye Kaixin, Devi, Gitali, Patil, Kiran M., Qu, Qiuyu, Maraswami, Manikantha, Xiao, Yunyun, Loh, Teck Peng, Zhao, Yanli, Chen, Gang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Cytosine; DNA
• Online Access: https://hdl.handle.net/10356/84061; http://hdl.handle.net/10220/42924
• Institution: Nanyang Technological University

RNA duplex regions are often involved in tertiary interactions and protein binding and thus there is great potential in developing ligands that sequence-specifically bind to RNA duplexes. We have developed a convenient synthesis method for a modified peptide nucleic acid (PNA) monomer with a guanidi...