Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

• Main Authors: Lee, K.-G., Xu, S., Kang, Z.-H., Huo, J., Huang, M., Liu, D., Takeuchi, O., Lam, K.-P., Akira, Shizuo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98238; http://hdl.handle.net/10220/12357
• Institution: Nanyang Technological University

Toll-like receptor 3 (TLR3) mediates antiviral response by recognizing double-stranded RNA. Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiates downstream signaling via the adapter TIR-containing adaptor inducing interferon–β (TRIF). However, the kinase responsible fo...