Acidic pH retards the fibrillization of human islet amyloid polypeptide due to electrostatic repulsion of histidines

• Main Authors: Li, Yang, Xu, Weixin, Mu, Yuguang, Zhang, John Z. H.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98369; http://hdl.handle.net/10220/13354
• Institution: Nanyang Technological University

The human Islet Amyloid Polypeptide (hIAPP) is the major constituent of amyloid deposits in pancreatic islets of type-II diabetes. IAPP is secreted together with insulin from the acidic secretory granules at a low pH of approximately 5.5 to the extracellular environment at a neutral pH. The increase...