Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations

The aggregation of human islet amyloid polypeptide (hIAPP or amylin) is associated with the pathogenesis of type 2 diabetes mellitus. Increasing evidence suggests that the interaction of hIAPP with β-cell membranes plays a crucial role in cytotoxicity. However, the hIAPP-lipid interaction and subseq...

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Bibliographic Details
Main Authors: Zhang, Yun, Luo, Yin, Deng, Yonghua, Mu, Yuguang, Wei, Guanghong
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/95431
http://hdl.handle.net/10220/9294
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Institution: Nanyang Technological University
Language: English