Palladium-catalyzed direct C-H arylation of enamides with simple arenes
Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential se...
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sg-ntu-dr.10356-984002020-03-07T12:34:47Z Palladium-catalyzed direct C-H arylation of enamides with simple arenes Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B). 2013-07-29T08:11:12Z 2019-12-06T19:54:51Z 2013-07-29T08:11:12Z 2019-12-06T19:54:51Z 2012 2012 Journal Article Pankajakshan, S., Xu, Y.-H., Cheng, J. K., Low, M. T., & Loh, T.-P. (2012). Palladium-Catalyzed Direct C-H Arylation of Enamides with Simple Arenes. Angewandte Chemie International Edition, 51(23), 5701-5705. 1433-7851 https://hdl.handle.net/10356/98400 http://hdl.handle.net/10220/12496 10.1002/anie.201109247 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Chemistry Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| description |
Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B). |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng |
| format |
Article |
| author |
Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng |
| author_sort |
Pankajakshan, Sreekumar |
| title |
Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_short |
Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_full |
Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_fullStr |
Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_full_unstemmed |
Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_sort |
palladium-catalyzed direct c-h arylation of enamides with simple arenes |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/98400 http://hdl.handle.net/10220/12496 |
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1681039690762813440 |