Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3′-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitate...
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sg-ntu-dr.10356-984722020-03-07T12:47:10Z Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms Rice, Scott A. Kardak, Bharat G. Howlin, Robert P. Webb, Jeremy S. Faust, Saul N. Kelso, Michael J. Barraud, Nicolas Yepuri, Nageshwar Rao Kjelleberg, Staffan Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3′-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. 2013-07-29T06:23:01Z 2019-12-06T19:55:35Z 2013-07-29T06:23:01Z 2019-12-06T19:55:35Z 2012 2012 Journal Article Barraud, N., Kardak, B. G., Yepuri, N. R., Howlin, R. P., Webb, J. S., Faust, S. N., et al. (2012). Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms. Angewandte Chemie International Edition, 51(36), 9057-9060. 1433-7851 https://hdl.handle.net/10356/98472 http://hdl.handle.net/10220/12454 10.1002/anie.201202414 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3′-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. |
| format |
Article |
| author |
Rice, Scott A. Kardak, Bharat G. Howlin, Robert P. Webb, Jeremy S. Faust, Saul N. Kelso, Michael J. Barraud, Nicolas Yepuri, Nageshwar Rao Kjelleberg, Staffan |
| spellingShingle |
Rice, Scott A. Kardak, Bharat G. Howlin, Robert P. Webb, Jeremy S. Faust, Saul N. Kelso, Michael J. Barraud, Nicolas Yepuri, Nageshwar Rao Kjelleberg, Staffan Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| author_facet |
Rice, Scott A. Kardak, Bharat G. Howlin, Robert P. Webb, Jeremy S. Faust, Saul N. Kelso, Michael J. Barraud, Nicolas Yepuri, Nageshwar Rao Kjelleberg, Staffan |
| author_sort |
Rice, Scott A. |
| title |
Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| title_short |
Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| title_full |
Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| title_fullStr |
Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| title_full_unstemmed |
Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms |
| title_sort |
cephalosporin-3′-diazeniumdiolates : targeted no-donor prodrugs for dispersing bacterial biofilms |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/98472 http://hdl.handle.net/10220/12454 |
| _version_ |
1681045520300113920 |