Cephalosporin-3′-diazeniumdiolates : targeted NO-donor prodrugs for dispersing bacterial biofilms

• Main Authors: Rice, Scott A., Kardak, Bharat G., Howlin, Robert P., Webb, Jeremy S., Faust, Saul N., Kelso, Michael J., Barraud, Nicolas, Yepuri, Nageshwar Rao, Kjelleberg, Staffan
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/98472; http://hdl.handle.net/10220/12454
• Institution: Nanyang Technological University

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3′-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitate...