Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin
Annulation: The efficient synthesis of 3-hydroxyalkyl isoquinolones and 6-hydroxyalkyl 2-pyridones is enabled through the intramolecular annulation of alkyne-tethered hydroxamic esters (see scheme, Cp*=pentamethylcyclopentadienyl). The reaction features high regioselectivity, broad substrate scope,...
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sg-ntu-dr.10356-985262020-03-07T12:34:47Z Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin Xu, Xianxiu Liu, Yu Park, Cheol-Min School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Annulation: The efficient synthesis of 3-hydroxyalkyl isoquinolones and 6-hydroxyalkyl 2-pyridones is enabled through the intramolecular annulation of alkyne-tethered hydroxamic esters (see scheme, Cp*=pentamethylcyclopentadienyl). The reaction features high regioselectivity, broad substrate scope, and excellent functional-group tolerance, proceeds under mild reaction conditions with low catalyst loading, and obviates the need for an external oxidant. 2013-07-29T08:01:09Z 2019-12-06T19:56:30Z 2013-07-29T08:01:09Z 2019-12-06T19:56:30Z 2012 2012 Journal Article Xu, X., Liu, Y., & Park, C.-M. (2012). Rhodium(III)-Catalyzed Intramolecular Annulation through C-H Activation: Total Synthesis of (±)-Antofine, (±)-Septicine, (±)-Tylophorine, and Rosettacin. Angewandte Chemie International Edition, 51(37), 9372-9376. 1433-7851 https://hdl.handle.net/10356/98526 http://hdl.handle.net/10220/12494 10.1002/anie.201204970 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Chemistry Xu, Xianxiu Liu, Yu Park, Cheol-Min Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
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Annulation: The efficient synthesis of 3-hydroxyalkyl isoquinolones and 6-hydroxyalkyl 2-pyridones is enabled through the intramolecular annulation of alkyne-tethered hydroxamic esters (see scheme, Cp*=pentamethylcyclopentadienyl). The reaction features high regioselectivity, broad substrate scope, and excellent functional-group tolerance, proceeds under mild reaction conditions with low catalyst loading, and obviates the need for an external oxidant. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Xu, Xianxiu Liu, Yu Park, Cheol-Min |
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Article |
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Xu, Xianxiu Liu, Yu Park, Cheol-Min |
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Xu, Xianxiu |
title |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
title_short |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
title_full |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
title_fullStr |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
title_full_unstemmed |
Rhodium(III)-catalyzed intramolecular annulation through C-H activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
title_sort |
rhodium(iii)-catalyzed intramolecular annulation through c-h activation : total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin |
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2013 |
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https://hdl.handle.net/10356/98526 http://hdl.handle.net/10220/12494 |
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