Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish

• Main Authors: Wang, Xingang, Zhao, Zhonghua, Muller, Julius, Iyu, Audrey, Khng, Alexis Jiaying, Guccione, Ernesto, Ruan, Yijun, Ingham, Philip William
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/98553; http://hdl.handle.net/10220/38599
• Institution: Nanyang Technological University

Hedgehog (Hh) signaling is mediated by the Gli transcription factors and, in the zebrafish, plays an important role in patterning both the neural tube and myotome. Using a null allele of the gli2a gene induced by targeted mutagenesis, we show that Gli2a is completely dispensable in the fish but acts...