TAK1, more than just innate immunity
Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-ter...
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sg-ntu-dr.10356-986692020-03-07T12:18:12Z TAK1, more than just innate immunity Dai, Liang Aye Thu, Chan Liu, Xin-Yu Xi, Jia Jia Cheung, Peter Ching For School of Biological Sciences DRNTU::Science::Biological sciences Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways. In addition, TAK1 plays a central role in adaptive immunity, in which it mediates signaling from T- and B-cell receptors. This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor-β, Wnt, osmotic stress, and hypoxia. 2013-10-25T03:02:16Z 2019-12-06T19:58:17Z 2013-10-25T03:02:16Z 2019-12-06T19:58:17Z 2012 2012 Journal Article Dai, L., Aye Thu, C., Liu, X.- Y., Xi, J. J., & Cheung, C. F. P. (2012). TAK1, more than just innate immunity. IUBMB Life, 64(10), 825-834. 1521-6543 https://hdl.handle.net/10356/98669 http://hdl.handle.net/10220/16896 10.1002/iub.1078 en IUBMB life © 2012 International Union of Biochemistry and Molecular Biology, Inc. |
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DRNTU::Science::Biological sciences Dai, Liang Aye Thu, Chan Liu, Xin-Yu Xi, Jia Jia Cheung, Peter Ching For TAK1, more than just innate immunity |
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Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), and p38 pathways. In addition, TAK1 plays a central role in adaptive immunity, in which it mediates signaling from T- and B-cell receptors. This review will focus on recent developments and also examine the regulation of TAK1 in response to a diverse range of other stimuli including DNA damage, transforming growth factor-β, Wnt, osmotic stress, and hypoxia. |
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School of Biological Sciences |
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School of Biological Sciences Dai, Liang Aye Thu, Chan Liu, Xin-Yu Xi, Jia Jia Cheung, Peter Ching For |
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Article |
| author |
Dai, Liang Aye Thu, Chan Liu, Xin-Yu Xi, Jia Jia Cheung, Peter Ching For |
| author_sort |
Dai, Liang |
| title |
TAK1, more than just innate immunity |
| title_short |
TAK1, more than just innate immunity |
| title_full |
TAK1, more than just innate immunity |
| title_fullStr |
TAK1, more than just innate immunity |
| title_full_unstemmed |
TAK1, more than just innate immunity |
| title_sort |
tak1, more than just innate immunity |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/98669 http://hdl.handle.net/10220/16896 |
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1681041594242826240 |