TAK1, more than just innate immunity

• Main Authors: Dai, Liang, Aye Thu, Chan, Liu, Xin-Yu, Xi, Jia Jia, Cheung, Peter Ching For
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98669; http://hdl.handle.net/10220/16896
• Institution: Nanyang Technological University

Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway. In response to interleukin-1, tumor necrosis factor-α, and toll-like receptor agonists, it mediates the activation of the nuclear factor κB (NF-κB), c-Jun N-ter...