Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

• Main Authors: Goh, Eddy T. H., Arthur, J. Simon C., Cheung, Peter Ching For, Akira, Shizuo, Toth, Rachel, Cohen, Philip
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98789; http://hdl.handle.net/10220/12739
• Institution: Nanyang Technological University

The E3 ubiquitin ligase Pellino 1 can be interconverted between inactive and active forms by a reversible phosphorylation mechanism. In vitro, phosphorylation and activation can be catalysed by either the IRAKs [IL (interleukin)-1-receptorassociated kinases] IRAK1 and IRAK4, or the IKK {IκB [in...