Structure and internal organization of overcharged cationic-lipid/peptide/DNA self-assembly complexes

• Main Authors: Yan, Jiang, Korolev, Nikolay, Su, Chun-Jen, Nordenskiöld, Lars, Berezhnoy, Nikolay V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98791; http://hdl.handle.net/10220/12747
• Institution: Nanyang Technological University

The combination of cationic lipids with cationic peptides and DNA vectors can produce synergistic effects in gene delivery to eukaryotic cells. Binary complexes of cationic lipids with DNA are well-studied whereas little information is available about the structure of the ternary lipid/peptide/DNA (...