The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

• المؤلفون الرئيسيون: Dip, Phat Vinh, Grüber, Gerhard, Marshansky, Vladimir, Hosokawa, H., Merkulova, M., Bakulina, A., Zhuang, Z., Khatri, A., Jian, X., Keating, S. M., Bueler, S. A., Rubinstein, J. L., Randazzo, P. A., Ausiello, D. A.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99231; http://hdl.handle.net/10220/17563
• المؤسسة: Nanyang Technological University

Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H+-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have studied the molecular mechanism of signaling between the V-ATPase, cyt...