The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2

• Main Authors: Dip, Phat Vinh, Grüber, Gerhard, Marshansky, Vladimir, Hosokawa, H., Merkulova, M., Bakulina, A., Zhuang, Z., Khatri, A., Jian, X., Keating, S. M., Bueler, S. A., Rubinstein, J. L., Randazzo, P. A., Ausiello, D. A.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2013
• 主題: DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/99231; http://hdl.handle.net/10220/17563

Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H+-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have studied the molecular mechanism of signaling between the V-ATPase, cyt...