Factors influencing polycation/siRNA colloidal stability toward aerosol lung delivery

Factors influencing polycation/siRNA colloidal stability toward aerosol lung delivery

Hexanediol diacrylate cross-linked oligoethylenimine (OEI-HD) is a non-viral polymeric vector designed to deliver siRNA. To achieve safe and effective in vivo siRNA delivery using this vector, the polyplex must have sufficient colloidal stability if administered intravenously or nebulized for delive...

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Bibliographic Details
Main Authors: Steele, Terry W. J., Zhao, Xiaobin, Tarcha, Peter, Kissel, Thomas
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Engineering::Materials
Online Access:https://hdl.handle.net/10356/99404
http://hdl.handle.net/10220/16219
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/99404
http://hdl.handle.net/10220/16219

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