Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium Pictet-Spengler sequence

An efficient approach for the solid-phase synthesis of structurally diverse heterocyclic compounds is presented. Under acidic reaction conditions, peptidic levulinamides undergo intramolecular ketone–amide condensation reactions to form cyclic N-acyliminium intermediates. In the presence of a tether...

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Bibliographic Details
Main Authors: Givskov, Michael, Komnatnyy, Vitaly V., Nielsen, Thomas E.
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/99417
http://hdl.handle.net/10220/13003
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Institution: Nanyang Technological University
Language: English