Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium Pictet-Spengler sequence

• Main Authors: Givskov, Michael, Komnatnyy, Vitaly V., Nielsen, Thomas E.
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99417; http://hdl.handle.net/10220/13003
• Institution: Nanyang Technological University

An efficient approach for the solid-phase synthesis of structurally diverse heterocyclic compounds is presented. Under acidic reaction conditions, peptidic levulinamides undergo intramolecular ketone–amide condensation reactions to form cyclic N-acyliminium intermediates. In the presence of a tether...