Bicyclic guanidinium-catalyzed enantioselective phase-transfer alkylation : direct access to pyrroloindolines and furoindolines

• Main Authors: Jiang, Zhiyong, Chen, Wenchao, Yang, Wenguo, Yan, Lin, Tan, Choon-Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/99510; http://hdl.handle.net/10220/17449
• Institution: Nanyang Technological University

Highly enantioselective phase-transfer alkylation of 3-substituted-2-oxindoles with activated bromomethanes is disclosed with a broad substrate scope by using bicyclic guanidinium as a catalyst and a Lewis acid as the co-catalyst. The alkylation adducts are versatile intermediates to accomplish the syntheses of pyrroloindolines and furoindolines.