Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti trypanosoma brucei agent

• Main Authors: Ngai, Mun Hong, Liu, Kai, Sheriff, Omar, Lear, Martin James, Sze, Siu Kwan, He, Cynthia Y., Yao, Shao Q., Yang, Peng-Yu, Wang, Min
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99512; http://hdl.handle.net/10220/12894
• Institution: Nanyang Technological University

Trypanosoma brucei is a parasite that causes African sleeping sickness in humans and nagana in livestock and is transmitted by the tsetse fly. There is an urgent need for the development of new drugs against African trypanosomiasis due to the lack of vaccines and effective drugs. Orlistat (also call...