Copper(II) Triflate catalyzed amination of 1,3-dicarbonyl compounds

• Main Authors: Ton, Thi My Uyen, Himawan, Fanny, Chang, Joyce Wei Wei, Chan, Philip Wai Hong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99536; http://hdl.handle.net/10220/12901
• Institution: Nanyang Technological University

A method to prepare α,α-acyl amino acid derivatives efficiently by Cu(OTf)2+1,10-phenanthroline (1,10-phen)-catalyzed amination of 1,3-dicarbonyl compounds with PhI[DOUBLE BOND]NSO2Ar is described. The mechanism is thought to initially involve aziridination of the enolic form of the substrate, forme...