Biomolecular engineering of a human beta defensin model for increased salt resistance

• Main Authors: Li, Xiang, Saravanan, Rathi, Kwak, Sang Kyu, Leong, Susanna Su Jan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/99615; http://hdl.handle.net/10220/17568
• Institution: Nanyang Technological University

Human beta defensins (hBDs) are natural antimicrobial peptides (AMPs) with broad spectrum antimicrobial activity. However, hBDs, like many AMPs, are easily inactivated by salt, which limits their extracellular applications as antimicrobial coating agents. In this study, a salt-resistant hBD28 peptid...