Fabrication of quercetin nanocrystals : comparison of different methods

The main aim of this study was to prepare quercetin nanocrystals using three fabrication methods, viz. high-pressure homogenization, bead milling, and cavi-precipitation. The three fabrication methods were compared in terms of particle size, saturation solubility, and dissolution of the products obt...

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Main Authors: Müller, Rainer H., Kakran, Mitali, Shegokar, Ranjita, Sahoo, Nanda Gopal, Al Shaal, Loaye, Li, Lin
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
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Online Access:https://hdl.handle.net/10356/99623
http://hdl.handle.net/10220/16217
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-996232020-03-07T13:22:19Z Fabrication of quercetin nanocrystals : comparison of different methods Müller, Rainer H. Kakran, Mitali Shegokar, Ranjita Sahoo, Nanda Gopal Al Shaal, Loaye Li, Lin School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering The main aim of this study was to prepare quercetin nanocrystals using three fabrication methods, viz. high-pressure homogenization, bead milling, and cavi-precipitation. The three fabrication methods were compared in terms of particle size, saturation solubility, and dissolution of the products obtained. The average particle size of the coarse quercetin was 50.1 μm. The three methods produced quercetin particles in the nanometre range (276–787 nm) and the smallest nanocrystals of around 276.7 nm were fabricated by bead milling. The particle size, polydispersity index, zeta potential, and saturation solubility values for the products fabricated by both high-pressure homogenization and bead mill were similar and thus both represented an efficient means to fabricate quercetin nanosuspensions. According to X-ray diffraction analysis, all nanocrystals were still in the crystalline state after being fabricated by the three methods. The cavi-precipitated product exhibited larger particle size and did not show an optimum stability as suggested by the zeta potential values. However, cavi-precipitated quercetin nanosuspension showed the higher saturation solubility due to the presence of ethanol. The bead milled products with the lowest particle size exhibited a saturation solubility of 25.59 ± 1.11 μg/ml, approximately nine times higher than coarse quercetin. Overall, the dissolution rates of the quercetin nanosuspensions fabricated by these three methods enhanced compared to the coarse quercetin. 2013-10-03T01:18:27Z 2019-12-06T20:09:36Z 2013-10-03T01:18:27Z 2019-12-06T20:09:36Z 2011 2011 Journal Article Kakran, M., Shegokar, R., Sahoo, N. G., Al Shaal, L., Li, L., & Müller, R. H. (2011). Fabrication of quercetin nanocrystals : comparison of different methods. European journal of pharmaceutics and biopharmaceutics, 80(1), 113-121. https://hdl.handle.net/10356/99623 http://hdl.handle.net/10220/16217 10.1016/j.ejpb.2011.08.006 en European journal of pharmaceutics and biopharmaceutics
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering
spellingShingle DRNTU::Engineering::Mechanical engineering
Müller, Rainer H.
Kakran, Mitali
Shegokar, Ranjita
Sahoo, Nanda Gopal
Al Shaal, Loaye
Li, Lin
Fabrication of quercetin nanocrystals : comparison of different methods
description The main aim of this study was to prepare quercetin nanocrystals using three fabrication methods, viz. high-pressure homogenization, bead milling, and cavi-precipitation. The three fabrication methods were compared in terms of particle size, saturation solubility, and dissolution of the products obtained. The average particle size of the coarse quercetin was 50.1 μm. The three methods produced quercetin particles in the nanometre range (276–787 nm) and the smallest nanocrystals of around 276.7 nm were fabricated by bead milling. The particle size, polydispersity index, zeta potential, and saturation solubility values for the products fabricated by both high-pressure homogenization and bead mill were similar and thus both represented an efficient means to fabricate quercetin nanosuspensions. According to X-ray diffraction analysis, all nanocrystals were still in the crystalline state after being fabricated by the three methods. The cavi-precipitated product exhibited larger particle size and did not show an optimum stability as suggested by the zeta potential values. However, cavi-precipitated quercetin nanosuspension showed the higher saturation solubility due to the presence of ethanol. The bead milled products with the lowest particle size exhibited a saturation solubility of 25.59 ± 1.11 μg/ml, approximately nine times higher than coarse quercetin. Overall, the dissolution rates of the quercetin nanosuspensions fabricated by these three methods enhanced compared to the coarse quercetin.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Müller, Rainer H.
Kakran, Mitali
Shegokar, Ranjita
Sahoo, Nanda Gopal
Al Shaal, Loaye
Li, Lin
format Article
author Müller, Rainer H.
Kakran, Mitali
Shegokar, Ranjita
Sahoo, Nanda Gopal
Al Shaal, Loaye
Li, Lin
author_sort Müller, Rainer H.
title Fabrication of quercetin nanocrystals : comparison of different methods
title_short Fabrication of quercetin nanocrystals : comparison of different methods
title_full Fabrication of quercetin nanocrystals : comparison of different methods
title_fullStr Fabrication of quercetin nanocrystals : comparison of different methods
title_full_unstemmed Fabrication of quercetin nanocrystals : comparison of different methods
title_sort fabrication of quercetin nanocrystals : comparison of different methods
publishDate 2013
url https://hdl.handle.net/10356/99623
http://hdl.handle.net/10220/16217
_version_ 1681044986712293376