Nanoscale-controlled enzymatic degradation of poly(L-lactic acid) films using dip-pen nanolithography

Nanoscale-controlled enzymatic degradation of poly(L-lactic acid) films using dip-pen nanolithography

Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegra...

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Bibliographic Details
Main Authors: Li, Hai, He, Qiyuan, Wang, Xiaohong, Lu, Gang, Liusman, Cipto, Li, Bing, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Zhang, Hua
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2012
Subjects:
DRNTU::Engineering::Mechanical engineering
Online Access:https://hdl.handle.net/10356/99642
http://hdl.handle.net/10220/8640
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Institution: Nanyang Technological University
Language: English
Description
Summary:Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.

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