Nanoscale-controlled enzymatic degradation of poly(L-lactic acid) films using dip-pen nanolithography

• Main Authors: Li, Hai, He, Qiyuan, Wang, Xiaohong, Lu, Gang, Liusman, Cipto, Li, Bing, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Zhang, Hua
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Engineering::Mechanical engineering
• Online Access: https://hdl.handle.net/10356/99642; http://hdl.handle.net/10220/8640
• Institution: Nanyang Technological University

Proteinase K is patterned on poly(L-lactic acid) (PLLA) film by agarose-assisted dip-pen nanolithography. Lateral biodegradation at the nanometer scale on PLLA film is faster than vertical biodegradation. The height and diameter of the patterned proteinase K dots can affect the depth of the biodegraded holes, while the concentration of the proteinase K solution (the ink used to coat the AFM tip) does not affect the biodegradation.